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KMID : 0043319870100020100
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Archives of Pharmacal Research
1987 Volume.10 No. 2 p.100 ~ p.102
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Inhibition of Platelet Aggregation by Colchicine, Thiocolchicine, and Their Phenolic and Glucosidic Congeners
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Brossi A
Dumont R/Yun-Choi HS/Lee JR
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Abstract
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Inhibition of platelet aggregation by colchicine, thiocolchicine, 0-demethylated and 3-glucosidic congeners was measured in vitro. 2- And 3-demethylated analogs of colchicine and thiocolchicine were found to be as potent as colchicine and thiocolchicine, respectively, whereas 1-demethylated compounds were found to be considerably less active. Both glucosides, colchicoside and thiocolchicoside, were not very active in this assay. 2,3-Didemethylcolchicine, which is much less toxic than colchicine, showed similar inhibitory effects on platelet aggregation as colchicine.
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